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By J. Knoll and K. Kelemen (Eds.)

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Additional info for Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985

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The present results indicate that anti-ischemic drugs have only limited efficacy on ventricular arrhythmia. The possible direct protection of ischemic myocardium by these drugs may have favorable effects on arrhythmia not by the suppression of myocardial ionic channels, as in the case of 1-camitine (Imai et al. 1985). , Shibuya,T. , 1982, Canine-effective plasma concentrations of antiarrhythmic drugs on the two-stage coronary ligation arrhythmia. Ther. 223:801-810. , Komori,S. , 1985, Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: A comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165.

1. L. Szekeres, J. Gy. Papp (eds) Myocardium CARDIOPROTECTIVE AND CEREBROPROTECTIVE EFFECT OF LIPOCORTIN-LIKE SUBSTANCES M . K O L T A I , I. L E P R Á N , Á . T O S A K I , L SZEKERES Department of Pharmacology, University Medical School, Szeged, Hungary Abstract Our previous experiments have showed that dexamethasone exerts a beneficial effect on myocardial and cerebral ischaemia induced by ligation of the main coronary artery, and of both common carotid arteries in awake rats. The protective effect was abolished by actinomycin D, indicating that the steroid action is generated at the level of genetic expression.

Heart J. 100:531-552. , Meo,F. , 1984, Beneficial effects of 1-camitine in the reduction of the necrotic area in acute myocardial infarction. Res. 10:219-223. , Hashimoto,K. , 1983, Effective plasma concentrations of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia in dogs. Pharmacol. 5:538-545. , Kamishiro,T,, Masaki,M. , 1982, Reduction of experimentally produced acute myocardial infarction size by a new synthetic inhibitor, NCO-700, against calcium-activated neutral protease.

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