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Download Advances in veterinary science and comparative medicine. by James L Bittle; Frederick A Murphy PDF

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By James L Bittle; Frederick A Murphy

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Extra info for Advances in veterinary science and comparative medicine. Vol. 33, Vaccine biotechnology

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A similar vaccine produced in BHK cells is also beneficial in animals. J. RETROVIRIDAE Retroviruses have a n RNA genome, a portion of which encodes the unique enzyme reverse transcriptase. This enzyme imparts to retroviruses the ability to make RNA-directed DNA copies of their genome, which can then act as a transposable element and can be integrated into the host cell DNA. Thus, once a cell is infected, it may escape immune surveillance and destruction and the host animal may be infected for life.

Canine Parainfluenza Virus. Outbreaks of mild respiratory disease in laboratory dogs have been attributed to parainfluenza type 2 virus (Binn et al, 1968; Crandell et al, 1968). When other respiratory agents such as mycoplasma and Bordetella bronchiseptica were given intranasally after exposure to this parainfluenza virus, more severe respiratory signs occurred (Appel and Percy, 1970). This encouraged efforts to develop a vaccine for canine parainfluenza virus. Immunization. An attenuated live-virus parainfluenza vaccine has been shown to protect dogs against aerosol challenge with virulent virus (Emery et al, 1976).

Novyi in animals employ chemically inactivated, detoxified, and adjuvanted suspensions of alum-precipitated formalinized whole broth cultures. 4. Clostridium chauvoei Clostridium chauvoei, which is the etiologic agent for the disease "blackleg" and is pathogenic for animals only, occurs primarily in ruminant species. , 1962). The necrotizing toxin may effect fatal toxemia with degenerative foci of myonecrosis. Immunization. Immunity to C. chauvoei can be produced via VACCINES PRODUCED BY CONVENTIONAL MEANS 41 vaccination with its alum-precipitated formalinized cultures (Chandler and Gulasekhuram, 1970).

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